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Protection of adrenal and male gonadal functions by androgen in lead-treated rats.
Artigo em Inglês | IMSEAR | ID: sea-46576
ABSTRACT
The potential health hazard of the large amounts of Lead that occurs in canned baby food, domestic water from lead-lined tanks and, in printing and petroleum industries. Lead acetate administration at a does of 8 mg/kg body weight for 21 days resulted a significant increase in adrenal steroidogenic enzyme (Delta5-3beta- HSD) and serum levels of corticosterone, while serum levels of testosterone, FSH, LH and testicular spermatogenesis were decreased in albino rats. But lead-treated rats received exogenous testosterone for the last 14 days of lead treatment, showed prevention of adrenocortical hyperactivity by decreasing adrenal Delta5-3beta-HSD activity and serum level of corticosterone. Testosterone administration also increased serum level of testosterone, FSH and LH along with spermatogenesis. The results suggest that testosterone supplementation in lead-treated rats protects adrenocortical activity and testicular spermatogenesis.
Assuntos
Texto completo: DisponíveL Índice: IMSEAR (Sudeste Asiático) Assunto principal: Tamanho do Órgão / Ratos / Espermatogênese / Testosterona / Masculino / Corticosterona / Córtex Suprarrenal / Hormônio Foliculoestimulante / Genitália Masculina / Androgênios Idioma: Inglês Ano de publicação: 2006 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: IMSEAR (Sudeste Asiático) Assunto principal: Tamanho do Órgão / Ratos / Espermatogênese / Testosterona / Masculino / Corticosterona / Córtex Suprarrenal / Hormônio Foliculoestimulante / Genitália Masculina / Androgênios Idioma: Inglês Ano de publicação: 2006 Tipo de documento: Artigo