Evaluation of anti-inflammatory activity of Calotropis gigantea (AKANDA) in various biological system.
Artigo
em Inglês
| IMSEAR
| ID: sea-46802
ABSTRACT
To evaluate the effect of Calotropis G in various experimental animal models. The anti-inflammatory activity was evaluated using carrageenin-induced kaolin -induced rat paw oedema for acute and cotton-pellet granuloma, adjuvant-induced arthritis model for chronic inflammation. Antipyretic activity was carried out using yeast induced pyresis method. Phenylquinone--induced writhing method in mice was used for analgesic activity. Test compounds exhibited variable anti-inflammatory activity and peak activity of the test compounds were reached at 2 h. Alkaloid fraction possesses comparatively high initial anti-inflammatory activity. The residual anti-inflammatory activity of alkaloid fraction of Calotropis G suggest either a greater protein binding nature of the compound there by providing a slow released pool of active drug molecule in the system or non available of possible bioactive metabolites to retain the activity profile relation.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Artrite Experimental
/
Ratos
/
Masculino
/
Extratos Vegetais
/
Fenilbutazona
/
Doença Crônica
/
Modelos Animais
/
Calotropis
/
Edema
/
Homeopatia
Tipo de estudo:
Estudo prognóstico
Idioma:
Inglês
Ano de publicação:
2006
Tipo de documento:
Artigo
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