Hormonal contraceptive like effect of estrogen in milk protein-fed male rats.
Artigo
em Inglês
| IMSEAR
| ID: sea-46871
ABSTRACT
Adult male rats received daily injections (sc) of estradiol-17 beta (50 microg/100 g body wt per day) for 7 days. When they were sacrificed 14 days after the last injection, serum levels of gonadotropins and testosterone and weights of accessory sex organs were decreased significantly, testicular 17-hydroxysteroid dehydroganase activity was suppressed and spermatogenesis was inhibited in 5.0% casein-fed estrogen-treated rats. Feeding of 20.0% casein diet to estrogen-treated rats resulted in increased serum concentration of gonadotropins and testosterone. LH and testosterone appeared to be normal in 20.0% casein-fed estrogen-treated rats while serum FSH levels remained subnormal. The estrogen-treated rats fed on 20.0% casein diet showed decreased spermatogenesis in comparison with control rats fed on 20.0% casein diet. Together, these results indicate that high casein diet stimulates synthesis of testicular testosterone and increases serum LH levels more than FSH in estrogen-treated rats. It is concluded that estrogen in the presence of high milk protein diet may be considered to be a suitable steroid hormone in the development of a male contraceptive.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Ratos
/
Espermatogênese
/
Masculino
/
Ratos Wistar
/
Anticoncepcionais
/
Estradiol
/
Hormônio Foliculoestimulante
/
17-Hidroxiesteroide Desidrogenases
/
Animais
/
Proteínas do Leite
Idioma:
Inglês
Ano de publicação:
2006
Tipo de documento:
Artigo
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