Management of acute paracetamol poisoning in a tertiary care hospital.
Ceylon Med J
;
2008 Sep; 53(3): 89-92
Artigo
em Inglês
| IMSEAR
| ID: sea-47307
ABSTRACT
OBJECTIVES:
To compare the management of acute paracetamol poisoning with the best evidence available, and to determine the effect of plasma paracetamol level estimation on the management.DESIGN:
Descriptive study with an intervention.SETTING:
Medical wards of the National Hospital of Sri Lanka, Colombo. PATIENTS Patients admitted with a history of acute paracetamol poisoning. INTERVENTION Measurement of plasma paracetamol.METHODS:
Data were obtained from the patients, medical staff and medical records. Plasma paracetamol was estimated between 4-24 hours of paracetamol ingestion. The current management practices were compared with the best evidence on acute paracetamol poisoning management.RESULTS:
157 patients were included. The mean ingested dose of paracetamol was 333 mg/kg body weight. Majority of the patients (84%) were transfers. Induced emesis and activated charcoal were given to 91% of patients. N-acetylcysteine was given to 66, methionine to 55, and both to 2. Aclinically important delay in the administration of antidotes was noted; 68% of patients received antidotes after 8 hours of the acute ingestion. Only 31 (26%) had paracetamol levels above the Rumack-Matthew normogram. 74 patients received an antidote despite having a plasma paracetamol level below the toxic level according to the normogram.INTERPRETATION:
Management of acute paracetamol poisoning could be improved by following best available evidence and adapting cheaper methods for plasma paracetamol estimation.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Intoxicação
/
Acetilcisteína
/
Sri Lanka
/
Fatores de Tempo
/
Feminino
/
Humanos
/
Masculino
/
Carvão Vegetal
/
Doença Aguda
/
Resultado do Tratamento
País/Região como assunto:
Ásia
Idioma:
Inglês
Revista:
Ceylon Med J
Ano de publicação:
2008
Tipo de documento:
Artigo
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