PCR detection and typing of human papilloma virus DNA in squamous carcinoma of the cervix in a cohort of Sri Lankan women.
Ceylon Med J
;
2006 Sep; 51(3): 114-7
Artigo
em Inglês
| IMSEAR
| ID: sea-47476
ABSTRACT
OBJECTIVE:
To determine the prevalence of human papilloma virus (HPV) types 16 and 18 in squamous carcinomas of the cervix in Sri Lanka.DESIGN:
Case control study.SETTING:
One gynaecological unit at the Cancer Institute, Maharagama, Sri Lanka. PATIENTS 15 patients with squamous carcinoma of the cervix, and 15 age matched controls with histologically normal cervices. MEASUREMENTS DNA was extracted from paraffin embedded cervical biopsies. Polymerase chain reaction was performed on extracted DNA employing primers specific for HPV types 16 and 18.RESULTS:
HPV 16 DNA was detected in 11 out of 15 cervical cancer biopsies (73.3%), in comparison with 3 out of 15 normal controls (20%). HPV 18 was detected in 3 out of 15 cervical cancer biopsies, but not in a single control biopsy.CONCLUSION:
Despite the limited number of cases in this cohort, this study supports the strong association between HPV 16 and squamous cancer of the cervix.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Sri Lanka
/
Biópsia
/
Feminino
/
Humanos
/
DNA Viral
/
Carcinoma de Células Escamosas
/
Estudos de Casos e Controles
/
Neoplasias do Colo do Útero
/
Reação em Cadeia da Polimerase
/
Fatores de Risco
Tipo de estudo:
Estudo diagnóstico
/
Estudo de etiologia
/
Estudo observacional
/
Fatores de risco
País/Região como assunto:
Ásia
Idioma:
Inglês
Revista:
Ceylon Med J
Ano de publicação:
2006
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS