Cytogenetic effect of thioridazine hydrochloride in mice and in human lymphocyte chromosomes.
Ceylon Med J
;
1991 Sep; 36(3): 102-5
Artigo
em Inglês
| IMSEAR
| ID: sea-47894
ABSTRACT
Thioridazine hydrochloride, a drug of the phenothiazine group with a piperidine side chain is widely used in human medicine as a psycho-relaxant and anxiolytic agent. The mutagenic effects of thioridazine hydrochloride were studied in Swiss albino mice. The animals were treated with 4, 6 and 8 mg/kg of thioridazine hydrochloride for the micronucleus test, analysis of chromosomes in germ cells, and for sperm morphology assay. Human lymphocyte cultures were treated in vitro with 0.75, 1.25 and 1.75 mg/culture of thioridazine hydrochloride for 24, 48 and 72 hours. The study showed no significant increase in the frequency of micronuclei, chromosomal aberrations in germ cells and sperm head abnormalities in mice, or chromosomal aberrations in human lymphocyte cultures.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Espermatócitos
/
Tioridazina
/
Humanos
/
Masculino
/
Linfócitos
/
Testes para Micronúcleos
/
Aberrações Cromossômicas
/
Animais
/
Camundongos
Idioma:
Inglês
Revista:
Ceylon Med J
Ano de publicação:
1991
Tipo de documento:
Artigo
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