Chloroquine resistant falciparum malaria among security forces personnel in the Northern Province of Sri Lanka.
Ceylon Med J
;
2004 Jun; 49(2): 47-51
Artigo
em Inglês
| IMSEAR
| ID: sea-47896
ABSTRACT
OBJECTIVE:
To determine the occurrence and species distribution of malaria and the extent of chloroquine resistance among security forces personnel in a selected region of the Northern Province of Sri Lanka.DESIGN:
A descriptive study.SETTING:
Mannar District in the Northern Province.METHODS:
Nine hundred and seventy five security personnel were screened for malaria by microscopy. Those who were positive were treated with chloroquine and were subjected to 28 day in vivo assay to determine chloroquine resistance. In vitro microtest assay was performed to determine the response of Plasmodium falciparum isolates to chloroquine in vitro.RESULTS:
Of the 975 personnel screened, 181 (18.6%) were positive for malaria. P. falciparum was the predominant species (n = 125; 69.1%). The rest were due to P. vivax (n = 42; 23.2%) and mixed infections (n = 14; 7.7%). This was an inversion of the usual species distribution pattern in the country. In vivo assay revealed 38 (53.5%) P. falciparum infections as chloroquine resistant. Fifteen of 23 (65.2%) P. falciparum isolates showed evidence of resistance in vitro. None of the P. vivax infections showed evidence of chloroquine resistance. There was no significant difference in the severity of clinical disease between chloroquine resistant and sensitive infections at first presentation. Recrudescent P. falciparum infections had significantly lower mean parasite densities as well as lower clinical scores at recrudescence than at first presentation.CONCLUSION:
Results demonstrate the high prevalence of malaria and chloroquine resistance in the study area and explains several contributory factors for this. There is an urgent need to review antimalarial drug policies in Sri Lanka.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Plasmodium falciparum
/
Sri Lanka
/
Humanos
/
Masculino
/
Resistência a Medicamentos
/
Cloroquina
/
Prevalência
/
Estudos Prospectivos
/
Malária Falciparum
/
Testes de Sensibilidade Parasitária
Tipo de estudo:
Estudo observacional
/
Estudo de prevalência
/
Fatores de risco
País/Região como assunto:
Ásia
Idioma:
Inglês
Revista:
Ceylon Med J
Ano de publicação:
2004
Tipo de documento:
Artigo
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