Maternal and cord blood levels of insulin-like growth factors--I and--II and insulin-like growth factor binding protein-1: correlation with birth weight and maternal anthropometric indices.
Ceylon Med J
;
2007 Jun; 52(2): 48-52
Artigo
em Inglês
| IMSEAR
| ID: sea-48740
ABSTRACT
OBJECTIVES:
To study the correlation of maternal and cord blood insulin like growth factor (IGF)-I and -II and IGF binding protein (IGFBP)-1 levels with birth weight and maternal anthropometric indices.DESIGN:
Longitudinal prospective study.SETTING:
Academic Institutions and a Tertiary Care Maternity Hospital.PARTICIPANTS:
Women with uncomplicated singleton pregnancy (N = 35) and their newborns. MEASUREMENTS Maternal weight, height, symphysiofundal height and serum levels of IGF-I, IGF-II, IGFBP-1 were measured thrice during the antenatal period, within 24 h of delivery and at 6 weeks and 6 months postpartum. Newborn anthropometric indices were recorded at birth, and at 6 weeks and 6 months of age. Cord blood levels of IGF-1, IGF-II, IGFBP-1, paternal height and weight, and placental weight measured.RESULTS:
Maternal and cord blood IGF-I levels were lower than values reported for Caucasians. All newborns showed adequate growth at birth, and up to 6 months of age. Cord blood IGF-1 positively correlated with chest circumference (r = 0.4532, P = 0.0262), IGFBP-1, negatively with birth weight (r = -0.4024, P = 0.0461) and IGF-II had no effect. Cord blood IGF-I positively correlated with maternal levels at 28 +/- 2 (r = 0.4571, P = 0.0247) and 36 +/- 2 (r = 0.4291, P = 0.0364) weeks of amenorrhoea, whereas IGF-II and IGFBP-1 did not correlate with maternal values. Maternal IGF-I, IGF-II and IGFBP-1 did not correlate with newborn or maternal anthropometric indices. Placental weight correlated significantly with birth weight (r = 0.5299, P = 0.0348) and head circumference (r = 0.5031, P = 0.0470).CONCLUSIONS:
Cord blood IGFBP-1 and placental weight appear to be determinants of birth weight variation even among appropriately grown for gestational age newborns.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Peso ao Nascer
/
Feminino
/
Humanos
/
Recém-Nascido
/
Gravidez
/
Fator de Crescimento Insulin-Like I
/
Fator de Crescimento Insulin-Like II
/
Resultado da Gravidez
/
Antropometria
/
Nível de Saúde
Tipo de estudo:
Estudo observacional
/
Estudo prognóstico
Idioma:
Inglês
Revista:
Ceylon Med J
Ano de publicação:
2007
Tipo de documento:
Artigo
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