Hyperhomocysteinaemia in Sri Lankan patients with coronary artery disease.
Ceylon Med J
;
2002 Sep; 47(3): 89-92
Artigo
em Inglês
| IMSEAR
| ID: sea-49153
ABSTRACT
OBJECTIVE:
To determine the association between hyperhomocysteinaemia and coronary artery disease (CAD) in a sample of Sri Lankans.DESIGN:
A case control study.SETTING:
Asiri Hospital, Kirula Road, Colombo 5, Sri Lanka.SUBJECTS:
105 patients with coronary artery disease and 112 controls.METHOD:
Fasting serum homocysteine levels were measured in 105 patients diagnosed as having CAD and in 112 unmatched controls. All patients admitted with clinical, electrocardiographical, biochemical or echocardiographical evidence of CAD were included in the study. Controls were selected from subjects admitted for health screening.RESULTS:
105 patients with CAD and 112 controls (unmatched for age and sex) were studied. A serum homocysteine level in excess of 18.2 mumol/l was considered high. Confounding effects of other conventional risk factors for CAD were controlled using multivariate logical regression analysis.CONCLUSION:
Hyperhomocysteinaemia is significantly associated with CAD. Multivariate logistic regression analysis indicated that the association between hyperhomocysteinaemia and CAD was confounded by other risk factors. However, statistical analysis revealed a significant independent association between hyperhomocysteinaemia and CAD (adjusted odds ratio = 2.881).
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Sri Lanka
/
Doença da Artéria Coronariana
/
Idoso
/
Feminino
/
Humanos
/
Masculino
/
Estudos de Casos e Controles
/
Comorbidade
/
Modelos Logísticos
/
Adulto
Tipo de estudo:
Estudo observacional
/
Estudo prognóstico
/
Fatores de risco
País/Região como assunto:
Ásia
Idioma:
Inglês
Revista:
Ceylon Med J
Ano de publicação:
2002
Tipo de documento:
Artigo
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