All-transretinoic acid and chemotherapy in the treatment of acute promyelocytic leukemia.
Indian J Cancer
;
2004 Jul-Sep; 41(3): 125-8
Artigo
em Inglês
| IMSEAR
| ID: sea-49943
ABSTRACT
BACKGROUND:
All-transretinoic acid (ATRA) and chemotherapy has improved complete remission rates and disease free survival in acute promyelocytic leukemia (APL). There is scanty data from Middle East.AIM:
To determine the efficacy of ATRA and multi-agent combination chemotherapy in treatment of APL in a single Centre in Kuwait. SET-UPS ANDDESIGN:
Tertiary cancer centre, retrospective study. METHODS ANDMATERIAL:
All newly diagnosed APL patients were treated with oral ATRA 45 mg/m2 daily until complete remission (CR), intravenous daunorubicin 50 mg/m2 on days 1,3 and 5, cytosine arabinoside 100 mg/m2 12 hrly on days 1 through 10 and etoposide 100 mg/m2 on days 1 through 5. Post remission three courses of intensive consolidation chemotherapy were administered. Since October 1999, maintenance chemotherapy consisting of oral 6 mercaptopurine 9 mg/m2 daily, methotrexate 15 mg/m2 weekly and ATRA 45 mg/m2 for 2 weeks every three months was added. Complete remission rates and duration, relapse rate and toxicity were studied.RESULTS:
22 of 24 evaluable patients (91.6%) achieved CR. The median duration of remission was 13 months (range 2-55 months). Three patients (12.5%) relapsed. Two patients (8.3%) developed retinoic acid syndrome and responded to dexamethasone. Five patients (20.8%) died one each of refractory disease, during remission induction and of relapse. Two patients died while in remission.CONCLUSION:
ATRA and combination chemotherapy results in high complete remission rates and low relapse rate in newly diagnosed APL. Maintenance therapy may be useful in preventing relapses.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Tretinoína
/
Indução de Remissão
/
Feminino
/
Humanos
/
Masculino
/
Leucemia Promielocítica Aguda
/
Protocolos de Quimioterapia Combinada Antineoplásica
/
Daunorrubicina
/
Metotrexato
/
Estudos Retrospectivos
Tipo de estudo:
Estudo observacional
Idioma:
Inglês
Revista:
Indian J Cancer
Ano de publicação:
2004
Tipo de documento:
Artigo
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