Prevalence and risk factors for development of lymphedema following breast cancer treatment.
Indian J Cancer
;
2004 Jan-Mar; 41(1): 8-12
Artigo
em Inglês
| IMSEAR
| ID: sea-50620
ABSTRACT
BACKGROUND:
Early detection and multimodality therapy has resulted in an overall improvement of survival among breast cancer patients. Despite a significant shift in the treatment approach from radical mastectomy to breast conservation a significant number of patients develop lymphedema. This study was conducted to evaluate the prevalence and risk factors for development of lymphedema. SETTINGS ANDDESIGN:
Retrospective analysis for prevalence of lymphedema in a tertiary care regional cancer centre. MATERIAL ANDMETHODS:
Three hundred treated breast cancer patients with a minimum follow up of one year were evaluated for the prevalence and risk factors for lymphedema. Lymphedema was assessed using a serial circumferential measurement method. More than 3 cm difference in circumference is considered as clinical significant lymphedema. Univariate and multivariate analysis were performed for evaluating the risk factors by using the Chi square test and Cox logistic regression analysis.RESULTS:
The prevalence of clinically significant lymphedema was 33.5 % and 17.2 % had severe lymphedema. The prevalence of lymphedema was 13.4 % in patients treated with surgery only where as the prevalence was 42.4% in patients treated with surgery and radiotherapy. Stage of the disease, body surface area > 1. 5 m2, presence of co-morbid conditions, post operative radiotherapy and anthracycline based chemotherapy were significant risk factors in univariate analysis where as axillary irradiation and presence of co-morbid conditions have emerged as independent risk factors in multivariate analysis (P < 0.001).CONCLUSION:
Post treatment lymphedema continues to be a significant problem following breast cancer therapy. Presence of co-morbid conditions and axillary radiation significantly increases the risk of lymphedema. A combination of axillary dissection and axillary radiation should be avoided whenever feasible to avoid lymphedema.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Superfície Corporal
/
Idoso de 80 Anos ou mais
/
Neoplasias da Mama
/
Idoso
/
Feminino
/
Humanos
/
Mastectomia Radical Modificada
/
Distribuição de Qui-Quadrado
/
Modelos Lineares
/
Modelos de Riscos Proporcionais
Tipo de estudo:
Estudo de etiologia
/
Estudo observacional
/
Estudo de prevalência
/
Estudo prognóstico
/
Fatores de risco
/
Estudo de rastreamento
Limite:
Aged80
Idioma:
Inglês
Revista:
Indian J Cancer
Ano de publicação:
2004
Tipo de documento:
Artigo
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