Patient profile and treatment outcome of rectal cancer patients treated with multimodality therapy at a regional cancer center.
Indian J Cancer
;
2004 Jul-Sep; 41(3): 120-4
Artigo
em Inglês
| IMSEAR
| ID: sea-51152
ABSTRACT
BACKGROUND:
Incidence of rectal cancer has wide geographical variation. Disease pattern in developing countries is different from developed countries as majority of the patients present in advanced stage because of delayed referral and lack of uniform treatment practices.AIMS:
Present study describes the patient profile and treatment results from a tertiary care cancer center in India. SETTING ANDDESIGN:
Tertiary care Regional cancer center. Retrospective analysis 89 patients with rectal adenocarcinoma treated between 1995 and 2002 were analyzed.METHODS:
Patients with adenocarcinoma rectum were evaluated in a G.I. Oncology clinic and were treated using multimodality protocols involving surgery, radiotherapy and adjuvant chemotherapy. STATISTICALANALYSIS:
A descriptive analysis of patient and disease profile, treatment patterns and out come was performed. Survival analysis was performed using Kaplan-Meier method.RESULTS:
Mean age of the patients was 45.4 years and majority of them had tumor in lower third of rectum with evidence of extrarectal spread. Seventy five percent of the patients underwent curative resection with abdominoperineal resection being the commonest procedure. Forty seven percent of patients were given short course preoperative radiotherapy and the remaining received postoperative radiotherapy. Sixty four percent of patients could complete planned adjuvant chemotherapy. Operative mortality was 2% and 23% had morbidity. Local recurrence rate was 8.9%. 5-year disease free and overall survival was 54% and 58% respectively.CONCLUSION:
Majority of rectal cancer patients present with locally advanced and low rectal growths leading to low sphincter salvage rates. Despite the advanced stage of presentation optimal oncologic results can be obtained by using a good surgical techniques in combination with adjuvant radiotherapy and chemotherapy. Short course preoperative radiotherapy seems to be more feasible in Indian context. Timely referral and uniform treatment guidelines throughout the country are needed for optimal management of rectal cancer in India.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Neoplasias Retais
/
Idoso de 80 Anos ou mais
/
Idoso
/
Feminino
/
Humanos
/
Masculino
/
Adenocarcinoma
/
Incidência
/
Taxa de Sobrevida
/
Estudos Retrospectivos
Tipo de estudo:
Estudo de etiologia
/
Guia de Prática Clínica
/
Estudo de incidência
/
Estudo observacional
/
Estudo prognóstico
/
Fatores de risco
Limite:
Aged80
País/Região como assunto:
Ásia
Idioma:
Inglês
Revista:
Indian J Cancer
Ano de publicação:
2004
Tipo de documento:
Artigo
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