Morphohistometric analysis of advancing tumor fronts in malignancies associated with oral submucous fibrosis.
Artigo
em Inglês
| IMSEAR
| ID: sea-51540
ABSTRACT
The objective of this study was to address retrospectively the invasive tumor fronts of epithelial neoplasms associated with OSF and non-associated tumors. Review of a data base of 25 OSF patients who have had concurrent oral squamous cell carcinoma served as the test sample. The controls constituted an equal number of age standardized (roughly) squamous cell carcinomas, non-associated with OSF. The diagnsis and grading were performed based on established criteria. Altogether a total of 8 histopathological variables were evaluated related to the advancing tumor fronts. After selection of cut-off levels, single parameter analysis by means of univariate test revealed significant result in none. A Total Malignancy Score (TMS) of 14.98 and 15.13(mean) were recorded for test and control respectively. Multivariate analysis showed that degree of nuclear plemorphism (p=0.015) and the pattern of invasion (p=0.003) were the only two variables which significantly affected the TMS. OSF associated tumors did not show features unique to it and therefore its response to therapy need not vary significantly from conventional cases.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Fibrose Oral Submucosa
/
Areca
/
Feminino
/
Humanos
/
Masculino
/
Neoplasias Bucais
/
Carcinoma de Células Escamosas
/
Estudos de Casos e Controles
/
Transformação Celular Neoplásica
/
Estudos Retrospectivos
Tipo de estudo:
Estudo observacional
/
Fatores de risco
Idioma:
Inglês
Ano de publicação:
2003
Tipo de documento:
Artigo
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