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Role of circulating immune complexes and platelet aggregation in the development of experimentally induced atherosclerosis in monkeys with normal intact vas deferens and following vasectomy.
Indian Heart J ; 1991 Jan-Feb; 43(1): 35-8
Artigo em Inglês | IMSEAR | ID: sea-5159
ABSTRACT
The study was undertaken in normal and vasectomized monkeys to elucidate the relationship of circulating immune complexes and platelet aggregability with experimental aortic and coronary atherosclerosis. Four groups of animals, viz. sham-vasectomized stock diet fed, vasectomized stock diet fed, sham-vasectomized atherogenic diet fed, were studied for a period of 1 year. An increased incidence of atherosclerosis was noted with high levels of circulating immune complexes in vasectomized monkeys. Platelets obtained from atherogenic diet fed monkeys had a clear tendency of increased aggregation and agglutination in the presence of ADP, epinephrine and ristocetin respectively. Vasectomy produced a significant enhancement in platelet aggregation response with ADP and epinephrine in atherogenic diet fed animals. The aortic and coronary atherosclerosis was also significantly increased in atherogenic diet fed groups both with and without vasectomy.
Assuntos
Texto completo: DisponíveL Índice: IMSEAR (Sudeste Asiático) Assunto principal: Arteriosclerose / Vasectomia / Masculino / Agregação Plaquetária / Animais / Macaca mulatta / Complexo Antígeno-Anticorpo Idioma: Inglês Revista: Indian heart j Ano de publicação: 1991 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: IMSEAR (Sudeste Asiático) Assunto principal: Arteriosclerose / Vasectomia / Masculino / Agregação Plaquetária / Animais / Macaca mulatta / Complexo Antígeno-Anticorpo Idioma: Inglês Revista: Indian heart j Ano de publicação: 1991 Tipo de documento: Artigo