Expression of E-cadherin in primary oral squamous cell carcinoma and metastatic lymph nodes: an immunohistochemical study.
Artigo
em Inglês
| IMSEAR
| ID: sea-51592
ABSTRACT
BACKGROUND:
E-cadherin plays an important role in cell-to-cell adhesion and cell motility and its loss is associated with oral squamous cell carcinoma (OSCC) progression. The aim of this study was to determine the expression of E-cadherin in various grades of OSCC and to correlate changes in the expression between these various grades and metastatic lymph nodes. MATERIALS ANDMETHODS:
Immunohistochemistry (IHC) was used to detect E-cadherin expression in normal oral mucosa, primary OSCC (n = 37), and metastatic lymph nodes (n = 10). E-cadherin immunoreactivity was correlated with grades of differentiation and with clinicopathological features.RESULTS:
E-cadherin immunoreactivity was found to inversely correlate with the loss of cell differentiation. The expression of E-cadherin decreased significantly in advanced cases of OSCC. However, increase in E-cadherin immunoreactivity was seen in early lesions, that is, in well differentiated (n = 9) and moderately differentiated OSCC (n = 13). Furthermore, E-cadherin was negative in majority of metastatic lymph nodes (7/10).CONCLUSIONS:
Loss of the cell adhesion and E-cadherin plays an important role in progression of OSCC, that is, down regulation of its expression is associated with de-differentiation and metastasis.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Humanos
/
Neoplasias Bucais
/
Carcinoma de Células Escamosas
/
Biomarcadores Tumorais
/
Caderinas
/
Regulação para Baixo
/
Regulação Neoplásica da Expressão Gênica
/
Adesão Celular
/
Diferenciação Celular
/
Técnicas Imunoenzimáticas
Idioma:
Inglês
Ano de publicação:
2009
Tipo de documento:
Artigo
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