Efficacy of antioxidants as an adjunct to photochemotherapy in vitiligo: a case study of 30 patients.

ABSTRACT

Low levels of antioxidant enzymes (catalase) have been demonstrated in the epidermis of vitiligo patients. Clinical trials with antioxidants as an adjunct to UVB phototherapy have shown encouraging results. The aim of this study was to determine the efficacy of oral antioxidants as an adjunct to photochemotherapy. Thirty patients of stable vitiligo, not on any treatment fort month were included in the study. Fifteen patients were treated with photochemotherapy alone and another 15 were treated with photochemotherapy and oral antiodixants (1 capsule od). Two index lesions were assessed in each patient, prior to treatment, 1 month and 3 months after treatment. Average area was calculated by Computer Aided Design. Patients were monitored for side effects to photochemotherapy and antioxidants. Percentage decrease in the area of index lesions was calculated after 3 months. No statistically significant difference was noted between the two regimes. No side effects specific to antioxidant therapy were observed. Antioxidants as an adjunct to photochemotherapy offer no distinct advantage and antioxidant therapy is free of adverse effects.