Cutaneous reactions simulating erythema multiforme and Stevens Johnson syndrome due to occupational exposure to a plant-growth regulator.
Indian J Dermatol Venereol Leprol
;
2007 Sep-Oct; 73(5): 330-2
Artigo
em Inglês
| IMSEAR
| ID: sea-52684
ABSTRACT
BACKGROUND:
In India, hydrogen cyanamide (Dormex) is a plant growth regulator used mainly for the bud-breaking of grapevines. The use of this chemical may result in severe cutaneous reactions simulating erythema multiforme (EM), Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN).METHODS:
Studies were conducted on four seasonal grapevine workers who developed severe cutaneous reactions following the unprotected use of Dormex (hydrogen cyanamide).RESULTS:
Two of the patients had EM-like skin lesions and the other two developed SJS-TEN-like skin lesions. A latent period of 5-7 days existed between the contact with the chemical and the development of the skin lesions. The histopathological picture was suggestive of EM. All the patients responded to systemic steroids and antihistamines.CONCLUSIONS:
Hydrogen cyanamide may act as a hapten, initiating cytotoxic immunological attack on keratinocytes, resulting in EM- and SJS-TEN-like clinical picture. Awareness regarding such severe cutaneous reactions due to the inappropriate handling of Dormex is required. The use of personal protection equipment while handling agricultural chemicals is essential.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Reguladores de Crescimento de Plantas
/
Feminino
/
Humanos
/
Masculino
/
Exposição Ocupacional
/
Dermatopatias Vesiculobolhosas
/
Adolescente
/
Eritema Multiforme
/
Síndrome de Stevens-Johnson
/
Agroquímicos
Tipo de estudo:
Estudo diagnóstico
Idioma:
Inglês
Revista:
Indian J Dermatol Venereol Leprol
Ano de publicação:
2007
Tipo de documento:
Artigo
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