A study of oxidative stress in paucibacillary and multibacillary leprosy.
Indian J Dermatol Venereol Leprol
;
2008 Jan-Feb; 74(1): 80
Artigo
em Inglês
| IMSEAR
| ID: sea-52860
ABSTRACT
BACKGROUND:
The study and assessment of oxidative stress plays a significant role in the arena of leprosy treatment.Once the presence of oxidative stress is proved, antioxidant supplements can be provided to reduce tissue injury and deformity.AIM:
To study oxidative stress in paucibacillary (PB) and multibacillary (MB) leprosy and to compare it with that in a control group.METHODS:
Fifty-eight untreated leprosy patients (23 PB and 35 MB cases) were studied and compared with 58 healthy controls. Superoxide dismutase (SOD) level as a measure of antioxidant status; malondialdehyde (MDA)level, an indicator of lipid peroxidation; and MDA/SOD ratio, an index of oxidative stress were estimated in the serum.RESULTS:
The SOD level was decreased in leprosy patients, especially in MB leprosy. The MDA level was increased in PB and MB leprosy. The MDA/SOD ratio was significantly elevated in MB patients. There was a steady increase in this ratio along the spectrum from tuberculoid to lepromatous leprosy (LL).CONCLUSION:
There is increased oxidative stress in MB leprosy, especially in LL. This warrants antioxidant supplements to prevent tissue injury.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Pele
/
Superóxido Dismutase
/
Humanos
/
Peroxidação de Lipídeos
/
Criança
/
Pré-Escolar
/
Adolescente
/
Estresse Oxidativo
/
Adulto
/
Hanseníase
Idioma:
Inglês
Revista:
Indian J Dermatol Venereol Leprol
Ano de publicação:
2008
Tipo de documento:
Artigo
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