Langerhans cell histiocytosis of skin: a clinicopathologic analysis of five cases.
Indian J Dermatol Venereol Leprol
;
2006 May-Jun; 72(3): 211-4
Artigo
em Inglês
| IMSEAR
| ID: sea-53042
ABSTRACT
BACKGROUND AND AIMS:
Langerhans cell histiocytosis (LCH) is a rare proliferative disorder of histiocytes characterized by a proliferation of abnormal and clonal Langerhans cells. We retrospectively studied clinicopathologic features of this disorder in five cases.METHODS:
Clinical and histopathological findings of five cases of cutaneous LCH were reviewed based on the hospital records.RESULTS:
The age of patients ranged from 28 days to 5 years and M F ratio was 11.5. Clinically, the diagnoses suggested were histiocytosis, varicella, transient neonatal pustular melanosis, keloid, sarcoidosis, seborrheic keratosis and LCH. The most common type of skin lesion was a generalized papular lesion. Histologically, all cases showed aggregates of large mononuclear histiocytes (Langerhans cells) with reniform, irregular, cleaved nuclei and abundant eosinophilic cytoplasm. There was multi-systemic involvement in two patients and single-system involvement in three patients.CONCLUSION:
Cutaneous lesions may be the sole presenting feature of LCH. Diagnosis is based on demonstration of S-100 positive histiocytes.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Pele
/
Feminino
/
Humanos
/
Masculino
/
Recém-Nascido
/
Pré-Escolar
/
Células de Langerhans
/
Histiocitose de Células de Langerhans
/
Estudos Retrospectivos
/
Adulto
Tipo de estudo:
Estudo observacional
Idioma:
Inglês
Revista:
Indian J Dermatol Venereol Leprol
Ano de publicação:
2006
Tipo de documento:
Artigo
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