Detection of pemphigus autoantibodies in healthy relatives of Turkish patients with pemphigus.
Indian J Dermatol Venereol Leprol
;
2007 Jul-Aug; 73(4): 240-2
Artigo
em Inglês
| IMSEAR
| ID: sea-53099
ABSTRACT
BACKGROUND:
Pemphigus autoantibodies have been reported in healthy relatives of pemphigus patients suggesting a genetic predisposition in the pathogenesis of the disease.AIMS:
To test for the presence of pemphigus autoantibodies in healthy relatives of Turkish patients of pemphigus.METHODS:
The study group comprised 45 pemphigus patients, 75 unaffected family members and 47 healthy individuals in the control group. Direct and indirect immunofluorescence techniques were performed to determine the presence of pemphigus autoantibodies.RESULTS:
By indirect immunofluorescence staining, circulating pemphigus autoantibodies were found in 26.7% of the relatives and in only two of the controls (P value = 0.0001). A direct immunofluorescence technique revealed positive results in three (4%) of the relatives and none of the controls.CONCLUSION:
The presence of pemphigus autoantibodies in clinically healthy relatives indicates that genetic predisposition is necessary but not sufficient for the development of clinical disease.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Pele
/
Autoanticorpos
/
Turquia
/
Biópsia
/
Idoso
/
Feminino
/
Humanos
/
Masculino
/
Imunoglobulina G
/
Imunofluorescência
Tipo de estudo:
Estudo diagnóstico
País/Região como assunto:
Ásia
Idioma:
Inglês
Revista:
Indian J Dermatol Venereol Leprol
Ano de publicação:
2007
Tipo de documento:
Artigo
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