Lichen amyloidosus: a study of clinical, histopathologic and immunofluorescence findings in 30 cases.
Indian J Dermatol Venereol Leprol
;
2005 May-Jun; 71(3): 166-9
Artigo
em Inglês
| IMSEAR
| ID: sea-53196
ABSTRACT
BACKGROUND:
Lichen amyloidosus (LA) is a primary localized cutaneous amyloidosis characterized clinically by discrete hyperkeratotic hyperpigmented papules and histologically by deposition of amyloid material in previously normal skin without any evidence of visceral involvement. AIMS ANDOBJECTIVES:
The aim of this work was to study the etiology, clinical features, histopathology and direct immunofluorescence findings in LA.METHODS:
A prospective study of 30 patients with clinical, histological and immunofluorescence findings suggestive of LA was undertaken. After a detailed history and clinical examination, two punch biopsies for histopathology and immunofluorescence were taken.RESULTS:
Of the 30 patients, 19 (63.3%) were males and 11 (36.7%) were females with duration of LA ranging from 6-20 months. Pruritus was the presenting symptom in 27 (90%) patients. Shin was involved in 26 (86.7%) followed by arms in three (10%) and back in one (3.3%). Seventeen patients (56%) had used scrubs for more than 2 years. Histopathology, direct immunofluorescence and Congo red staining detected amyloid in all cases.CONCLUSIONS:
LA commonly presents over the shins as pruritic discrete hyperpigmented papules. Familial predisposition and friction may have a pathogenic role. Histopathological examination is very useful in the detection of amyloid which may be supplemented with direct immunofluorescence and Congo red staining.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Pele
/
Biópsia por Agulha
/
Índice de Gravidade de Doença
/
Feminino
/
Humanos
/
Masculino
/
Imuno-Histoquímica
/
Incidência
/
Estudos Prospectivos
/
Seguimentos
Tipo de estudo:
Estudo de incidência
/
Estudo observacional
/
Estudo prognóstico
/
Fatores de risco
País/Região como assunto:
Ásia
Idioma:
Inglês
Revista:
Indian J Dermatol Venereol Leprol
Ano de publicação:
2005
Tipo de documento:
Artigo
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