Prevalence of hepatitis C virus (HCV) coinfection in HIV infected individuals in south India and characterization of HCV genotypes.
Indian J Med Microbiol
;
2009 Jan-Mar; 27(1): 12-6
Artigo
em Inglês
| IMSEAR
| ID: sea-53559
ABSTRACT
PURPOSE:
To determine anti-HCV antibodies and genomic subtype of HCV in 1487 confirmed human immunodeficiency virus (HIV) positive samples.METHODS:
A total of 1487 confirmed HIV-positive samples were tested for anti-HCV antibodies by using a third generation ELISA kit (Ortho 3.0) and by RT PCR for HCV. HIV and HCV coinfected samples were selected for HCV genotyping by RFLP and subtyping with NS5-type specific primers.RESULTS:
A total of 1487 HIV-infected serum samples were screened for HCV infection, of which, a 1443 (97.04%) were negative and 45 (3.02%) were coinfected. HIV-HCV coinfection was predominant in the age group 41-50 years (51.1%). HCV genotyping and subtyping was done for the 45 HCV RNA-positive specimens of which genotype 1 was observed in 31 (68.8%) and genotype 3 was observed in 14 (31.1%) subjects. Further subtyping analysis showed the genotype 1b in 23 (51.1%), 1a in eight (17.7%), 3a in 10 (22.2%) and 3b in four (8.8%) subjects.CONCLUSION:
HIV and HCV seroprevalence is higher in South India, and the most prevalent genotype in coinfection was genotype 1b.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Polimorfismo de Fragmento de Restrição
/
Feminino
/
Humanos
/
Masculino
/
RNA Viral
/
Ensaio de Imunoadsorção Enzimática
/
Comorbidade
/
Infecções por HIV
/
Prevalência
/
Fatores Etários
Tipo de estudo:
Estudo de prevalência
/
Fatores de risco
País/Região como assunto:
Ásia
Idioma:
Inglês
Revista:
Indian J Med Microbiol
Assunto da revista:
Microbiology
Ano de publicação:
2009
Tipo de documento:
Artigo
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