Effect of exposure to hydrogen peroxide on the virulence of Escherichia coli.
Indian J Med Microbiol
;
2008 Jan-Mar; 26(1): 25-8
Artigo
em Inglês
| IMSEAR
| ID: sea-53651
ABSTRACT
PURPOSE:
To eliminate pathogenic bacteria, the host presents conditions that are stressful for bacteria. Oxidative stress arises when the concentration of pro-oxidants like hydrogen peroxide (H2O2 ) and superoxide anion increases to a level over the basal defence capacity of the cell. In the present study, we studied the effect of oxidative stress on the production of certain virulence factors by Escherichia coli .METHODS:
E. coli was exposed to oxidative stress by growing in the presence of different concentrations of H2O2 . The effect of oxidative stress on the expression of surface hydrophobicity, adherence, haemolysin production, serum resistance and phagocytosis was studied.RESULTS:
Oxidative stress caused a significant decrease in the expression of all the virulence factors of E. coli .CONCLUSIONS:
Synthesis of virulence factors can be significantly altered by oxidative stress and such changes may affect the pathogenicity of E. coli.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Fagocitose
/
Virulência
/
Aderência Bacteriana
/
Humanos
/
Proteínas de Escherichia coli
/
Fatores de Virulência
/
Escherichia coli
/
Interações Hidrofóbicas e Hidrofílicas
/
Proteínas Hemolisinas
/
Peróxido de Hidrogênio
Idioma:
Inglês
Revista:
Indian J Med Microbiol
Assunto da revista:
Microbiology
Ano de publicação:
2008
Tipo de documento:
Artigo
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