Detection of extra-cellular enzymes of anaerobic gram-negative bacteria from clinically diseased and healthy sites.
Indian J Med Microbiol
;
2008 Jan-Mar; 26(1): 65-7
Artigo
em Inglês
| IMSEAR
| ID: sea-54053
ABSTRACT
Anaerobic gram-negative bacteria (AGNB) produce enzymes that play a significant role in the development of disease. We tested 50 AGNB isolates, 25 each from clinically diseased and healthy human sites for in vitro production of caseinase, collagenase, etc. Majority of the isolates were Bacteroides fragilis and Porphyromonas gingivalis, which more commonly produced collagenase and haemolysin. Comparatively larger number of clinical AGNB produced collagenase (P = 0.004). No such difference was observed with other enzymes. Hence, collagenase is probably one of the key virulence markers of pathogenic AGNB, and the inhibitors targeting collagenases might help in the therapy of anaerobic infections.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Proteínas de Bactérias
/
Humanos
/
Infecções por Bactérias Gram-Negativas
/
Fatores de Virulência
/
Enzimas
/
Bactérias Anaeróbias Gram-Negativas
Tipo de estudo:
Estudo diagnóstico
Idioma:
Inglês
Revista:
Indian J Med Microbiol
Assunto da revista:
Microbiology
Ano de publicação:
2008
Tipo de documento:
Artigo
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