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Effect of T-cell depletion on bacterial multiplication and pattern of nerve damage in M. leprae-infected mice.
Indian J Lepr ; 1995 Oct-Dec; 67(4): 363-74
Artigo em Inglês | IMSEAR | ID: sea-54232
ABSTRACT
Various mechanisms for nerve damage in tuberculoid leprosy have been proposed. A common feature amongst them is the crucial role played by T-cells. Therefore, the present study was designed to determine the role of T-cells in the induction of nerve damage in leprosy using two different protocols for obtaining graded levels of T-cell depletion (i) Cyclosporine A, for depletion of T-helper cells and (ii) Anti Thy 1.2, for total depletion of T-cells. The findings indicate that the early changes seen in the unmyelinated fibres may not involve T-cells. However, the later stages of nerve damage associated with demyelination are dependent on T-cell responses.
Assuntos
Texto completo: DisponíveL Índice: IMSEAR (Sudeste Asiático) Assunto principal: Nervo Isquiático / Feminino / Linfócitos T / Doenças Desmielinizantes / Ciclosporina / Isoanticorpos / Hanseníase / Animais / Camundongos / Mycobacterium leprae Idioma: Inglês Revista: Indian J Lepr Assunto da revista: Tropical Medicine Ano de publicação: 1995 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: IMSEAR (Sudeste Asiático) Assunto principal: Nervo Isquiático / Feminino / Linfócitos T / Doenças Desmielinizantes / Ciclosporina / Isoanticorpos / Hanseníase / Animais / Camundongos / Mycobacterium leprae Idioma: Inglês Revista: Indian J Lepr Assunto da revista: Tropical Medicine Ano de publicação: 1995 Tipo de documento: Artigo