Effect of T-cell depletion on bacterial multiplication and pattern of nerve damage in M. leprae-infected mice.
Indian J Lepr
;
1995 Oct-Dec; 67(4): 363-74
Artigo
em Inglês
| IMSEAR
| ID: sea-54232
ABSTRACT
Various mechanisms for nerve damage in tuberculoid leprosy have been proposed. A common feature amongst them is the crucial role played by T-cells. Therefore, the present study was designed to determine the role of T-cells in the induction of nerve damage in leprosy using two different protocols for obtaining graded levels of T-cell depletion (i) Cyclosporine A, for depletion of T-helper cells and (ii) Anti Thy 1.2, for total depletion of T-cells. The findings indicate that the early changes seen in the unmyelinated fibres may not involve T-cells. However, the later stages of nerve damage associated with demyelination are dependent on T-cell responses.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Nervo Isquiático
/
Feminino
/
Linfócitos T
/
Doenças Desmielinizantes
/
Ciclosporina
/
Isoanticorpos
/
Hanseníase
/
Animais
/
Camundongos
/
Mycobacterium leprae
Idioma:
Inglês
Revista:
Indian J Lepr
Assunto da revista:
Tropical Medicine
Ano de publicação:
1995
Tipo de documento:
Artigo
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