In vitro and in vivo interactions of drugs used in multidrug therapy in leprosy.
Indian J Lepr
;
1991 Apr-Jun; 63(2): 166-79
Artigo
em Inglês
| IMSEAR
| ID: sea-54510
ABSTRACT
Interactions of different drugs commonly used in multiple drug therapy were evaluated using both in vitro culture (cell-free as well as macrophage) system and mouse footpad. No additive effects were obtained in the in vitro system when dapsone was combined with either rifampicin or clofazimine, while a strong antagonism was observed when clofazimine was combined with rifampicin but not with rifabutin. In the mouse footpad system, a strong synergism was obtained when clofazimine was combined with either rifampicin or rifabutin, but significant antagonism was observed with the combination of clofazimine and dapsone.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Rifampina
/
Rifamicinas
/
Testes de Sensibilidade Microbiana
/
Clofazimina
/
Rifabutina
/
Meios de Cultura
/
Dapsona
/
Interações Medicamentosas
/
Quimioterapia Combinada
/
Hansenostáticos
Idioma:
Inglês
Revista:
Indian J Lepr
Assunto da revista:
Tropical Medicine
Ano de publicação:
1991
Tipo de documento:
Artigo
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