Computerized mathematical model of M. leprae population dynamics during multiple drug therapy.
Indian J Lepr
;
1985 Oct-Dec; 57(4): 780-9
Artigo
em Inglês
| IMSEAR
| ID: sea-54708
ABSTRACT
A computerized mathematical model of M. leprae populations during multiple drug therapy (MDT) was constructed. Relevant published information available to date was fed into it, and reasoned assumptions were made. From the model, it seems likely that MDT steadily selects bacteria resistant to the most powerful of the three drugs used unless the individual bactericidal potencies of the drugs balance one another. If the drugs used have differing potencies, cure probably hinges on treatment being continued until all metabolically active bacteria are killed. Withdrawal of treatment before that could lead to relapse with bacteria resistant to the most powerful of the drugs used.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Software
/
Humanos
/
Resistência Microbiana a Medicamentos
/
Quimioterapia Combinada
/
Hanseníase
/
Matemática
/
Modelos Biológicos
/
Mutação
/
Mycobacterium leprae
Idioma:
Inglês
Revista:
Indian J Lepr
Assunto da revista:
Tropical Medicine
Ano de publicação:
1985
Tipo de documento:
Artigo
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