Metabolic studies on mycobacteria. IV. Assay of isocitrate lyase and malate synthase activity in M. leprae.
Indian J Lepr
;
1987 Apr-Jun; 59(2): 158-62
Artigo
em Inglês
| IMSEAR
| ID: sea-54796
ABSTRACT
Cell free extracts from M. tuberculosis H37 Rv, M. smegmatis armadillo derived M. leprae and normal armadillo liver homogenates were assayed for the presence of isocitrate lyase and malate synthase activity. It was observed that significant amount of isocitrate lyase and malate synthase activity was present in M. tuberculosis H37 Rv, M. smegmatis and armadillo derived M. leprae. No such activity was demonstrable in cell free extracts of normal armadillo liver. It is concluded that M. leprae like other mycobacteria has the capability to metabolise via glyoxylate bypass of TCA cycle. These findings may be relevant for understanding the energy metabolism of M. leprae under stress conditions and possibly the 'persister' stage.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Tatus
/
Isocitrato Liase
/
Oxo-Ácido-Liases
/
Fígado
/
Animais
/
Malato Sintase
/
Mycobacterium
/
Mycobacterium leprae
/
Mycobacterium tuberculosis
Idioma:
Inglês
Revista:
Indian J Lepr
Assunto da revista:
Tropical Medicine
Ano de publicação:
1987
Tipo de documento:
Artigo
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