Effect of brodimoprim on Mycobacterium leprae in vitro and in mouse foot-pads.
Indian J Lepr
;
1990 Jan-Mar; 62(1): 76-86
Artigo
em Inglês
| IMSEAR
| ID: sea-54900
ABSTRACT
The new in vitro screening system reported earlier was adopted to determine anti-M. leprae activity of a dihydrofolate reductase inhibitor, brodimoprim, and the results were compared with those obtained using mouse foot-pad technique. Even though the MIC of brodimoprim against M. leprae was very high compared to other commonly used anti-leprosy drugs, in combination with dapsone it showed a remarkable synergistic activity in inhibiting the growth of M. leprae at concentrations much lower than the MICs of each of the drugs used singly. Similar effects were also demonstrated in mouse foot-pad experiments.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Trimetoprima
/
Dapsona
/
Sinergismo Farmacológico
/
Hansenostáticos
/
Animais
/
Camundongos
/
Camundongos Endogâmicos BALB C
/
Mycobacterium leprae
Idioma:
Inglês
Revista:
Indian J Lepr
Assunto da revista:
Tropical Medicine
Ano de publicação:
1990
Tipo de documento:
Artigo
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