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Effect of brodimoprim on Mycobacterium leprae in vitro and in mouse foot-pads.
Indian J Lepr ; 1990 Jan-Mar; 62(1): 76-86
Artigo em Inglês | IMSEAR | ID: sea-54900
ABSTRACT
The new in vitro screening system reported earlier was adopted to determine anti-M. leprae activity of a dihydrofolate reductase inhibitor, brodimoprim, and the results were compared with those obtained using mouse foot-pad technique. Even though the MIC of brodimoprim against M. leprae was very high compared to other commonly used anti-leprosy drugs, in combination with dapsone it showed a remarkable synergistic activity in inhibiting the growth of M. leprae at concentrations much lower than the MICs of each of the drugs used singly. Similar effects were also demonstrated in mouse foot-pad experiments.
Assuntos
Texto completo: DisponíveL Índice: IMSEAR (Sudeste Asiático) Assunto principal: Trimetoprima / Dapsona / Sinergismo Farmacológico / Hansenostáticos / Animais / Camundongos / Camundongos Endogâmicos BALB C / Mycobacterium leprae Idioma: Inglês Revista: Indian J Lepr Assunto da revista: Tropical Medicine Ano de publicação: 1990 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: IMSEAR (Sudeste Asiático) Assunto principal: Trimetoprima / Dapsona / Sinergismo Farmacológico / Hansenostáticos / Animais / Camundongos / Camundongos Endogâmicos BALB C / Mycobacterium leprae Idioma: Inglês Revista: Indian J Lepr Assunto da revista: Tropical Medicine Ano de publicação: 1990 Tipo de documento: Artigo