In vivo activities of novel benzoxazinorifamycins against Mycobacterium leprae.
Indian J Lepr
;
1995 Oct-Dec; 67(4): 375-82
Artigo
em Inglês
| IMSEAR
| ID: sea-55488
ABSTRACT
Among the four newly synthesized benzoxazinorifamycin derivatives, KRM-1648 and KRM-2312 completely inhibited the multiplication of rifampicin-sensitive as well as rifampicin-resistant strains of M. leprae in the foot-pads of mice. Both were found to be more potent than rifampicin and were bactericidal. In combination with ofloxacin, another potent bactericidal drug against M. leprae, both KRM-1648 and KRM-2312 exhibited synergism. Thus, combination of one of these benzoxazinorifamycin derivatives and ofloxacin in multidrug regimens is worth evaluating in clinical trials.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Rifamicinas
/
Hansenostáticos
/
Animais
/
Camundongos
/
Camundongos Endogâmicos BALB C
/
Mycobacterium leprae
Idioma:
Inglês
Revista:
Indian J Lepr
Assunto da revista:
Tropical Medicine
Ano de publicação:
1995
Tipo de documento:
Artigo
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