Does TAME induced contraction involve an endothelium dependent nitric oxide-cyclic GMP mediated pathway?
Artigo
em Inglês
| IMSEAR
| ID: sea-55610
ABSTRACT
Two enzyme inhibitors namely L-NAME, a nitric oxide synthase (NOS) inhibitor and methylene blue, a guanylate cyclase inhibitor, were used to elucidate whether N-alpha-tosyl L-arginine methyl ester (TAME)-induced contractions in toad intestinal rings in vitro are mediated through a nitric oxide (NO)- cyclic GMP (c-GMP) pathway. Moreover, a NO precursor, L-arginine was also used to investigate its effect on TAME-induced contractions. Our findings provide evidence that TAME-induced contractions have both an endothelium-dependent and an endothelium-independent component. Based on our findings we now propose that TAME induced contraction involves an endothelium-dependent component mediated through NO and c-GMP.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Tosilarginina Metil Éster
/
Bufonidae
/
Endotélio Vascular
/
GMP Cíclico
/
NG-Nitroarginina Metil Éster
/
Íleo
/
Animais
/
Azul de Metileno
/
Contração Muscular
/
Músculo Liso
Idioma:
Inglês
Ano de publicação:
1999
Tipo de documento:
Artigo
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