Neurobehavioral effects of low level fenvalerate exposure in mice.
Indian J Exp Biol
;
1997 Jun; 35(6): 623-7
Artigo
em Inglês
| IMSEAR
| ID: sea-55636
ABSTRACT
Effect of oral administration of fenvalerate, a pyrethroid insecticide was studied in different behavioral paradigms in mice. Fenvalerate at 15, 30 and 45 mg/kg dose increased start latency, decreased ambulation and rearing in open-field, increased immobility in tail-suspension test and attenuated haloperidol-induced catalepsy in a dose-dependent manner. The time-course of data shows that these effects of fenvalerate may sustain up to several hours of its oral administration. The study indicates that pyrethroids can cause adverse behavioral effects even after a very low-level exposure. Although, it is difficult to extrapolate these findings directly to behavioral changes in man, they indicate that subtle behavioral dysfunction also occur in humans at exposures which do not cause acute toxicity.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Piretrinas
/
Masculino
/
Catalepsia
/
Elevação dos Membros Posteriores
/
Relação Dose-Resposta a Droga
/
Comportamento Exploratório
/
Inseticidas
/
Animais
/
Camundongos
/
Nitrilas
Idioma:
Inglês
Revista:
Indian J Exp Biol
Ano de publicação:
1997
Tipo de documento:
Artigo
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