Development effect of technical dimethoate in rats: maternal and fetal toxicity evaluation.

ABSTRACT

Technical dimethoate was administered orally to pregnant rats through day 6-20 of gestation at doses 3.75, 7.5, 15 and 30 mg/kg/day. Dose of 30 mg/kg/day produced high mortality rate in dams and was not considered for developmental toxicity evaluation. Dimethoate produced enzymatic changes in liver of dams associated with mild pathomorphological changes in liver and brain. Significant fetotoxic effects were not observed at the tested dose levels as evidenced by total number of implantations, percentage resorption, and live fetuses except reduction in fetal weight. Reduced acetylcholinesterase activity in fetal brain and placenta at higher dose levels indicated possible transmigration of dimethoate from dams to fetuses. The absence of anomalies in fetal gross, visceral morphology and skeleton suggests technical dimethoate as non teratogenic in rat at tested dose levels.