Antihepatotoxic effect of beta-carotene on paracetamol induced hepatic damage in rats.
Indian J Exp Biol
;
2005 Apr; 43(4): 351-5
Artigo
em Inglês
| IMSEAR
| ID: sea-55793
ABSTRACT
Enzyme levels of serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT) and alkaline phosphatase (ALP) increased following paracetamol induction were significantly lowered due to pretreatment with the beta-carotene (BC). This supplementation reversed the trend inducing a significant decrease in bilirubin and urea levels. Paracetamol administration significantly reduced hepatic glycogen, glutathione (GSH), glutathione-S-transferase (GST), glutathione peroxidase (GPX) and glutathione reductase (GSH-R). Pretreatment of rats with BC significantly increased the enzyme activities. The results suggest hepatoprotective activity of BC.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Ratos
/
Ratos Wistar
/
Analgésicos não Narcóticos
/
Beta Caroteno
/
Modelos Animais de Doenças
/
Doença Hepática Induzida por Substâncias e Drogas
/
Fígado
/
Animais
/
Acetaminofen
/
Antioxidantes
Idioma:
Inglês
Revista:
Indian J Exp Biol
Ano de publicação:
2005
Tipo de documento:
Artigo
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