Poly (DL-lactide-co-glycolide) microparticles as carriers for antimycobacterial drug rifampicin.
Indian J Exp Biol
;
2000 Sep; 38(9): 887-94
Artigo
em Inglês
| IMSEAR
| ID: sea-55802
ABSTRACT
Poly (DL-lactide-co-glycolide) polymers were investigated as carriers for the first line antitubercular drug rifampicin. Different formulations of PLG microparticles viz. porous, non porous and hardened exhibited sustained release of rifampicin up to 7 weeks in vitro. However, hardened PLG microparticles exhibited the most sustained release in vivo in different organs up to 6 weeks. In case of free rifampicin, release was detected in vivo only up to 48 hr. In addition, no hepatotoxicity was observed on a biochemical basis (levels of SGPT, ALP and total bilirubin) in comparison to control animals. Taken together, these results suggest that polymer encapsulated antitubercular drug rifampicin may serve as an ideal therapeutic approach for treatment of tuberculous infections.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Tamanho da Partícula
/
Ácido Poliglicólico
/
Polímeros
/
Rifampina
/
Bilirrubina
/
Materiais Biocompatíveis
/
Feminino
/
Masculino
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Portadores de Fármacos
/
Sistemas de Liberação de Medicamentos
Idioma:
Inglês
Revista:
Indian J Exp Biol
Ano de publicação:
2000
Tipo de documento:
Artigo
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