Mast cell stabilizing and lipoxygenase inhibitory activity of Cedrus deodara (Roxb.) Loud. wood oil.
Indian J Exp Biol
;
1999 Mar; 37(3): 258-61
Artigo
em Inglês
| IMSEAR
| ID: sea-55997
ABSTRACT
Volatile oil of C. deodara, administered orally at the doses of 50, 100 and 200 mg/kg body weight, significantly inhibited the pedal edema induced by compound 48/80 in rats. The oil significantly inhibited compound 48/80 induced degranulation of isolated rat peritoneal mast cells at concentrations ranging from 25-200 micrograms/ml. C. deodara wood oil also significantly inhibited the enzyme lipoxygenase at a concentration of 200 micrograms/ml. Thus, the anti-inflammatory activity of C. deodara wood oil could be attributed to its mast cell stabilizing activity and the inhibition of leukotriene synthesis.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Ratos
/
Árvores
/
Óleos de Plantas
/
Masculino
/
Degranulação Celular
/
Anti-Inflamatórios não Esteroides
/
Inibidores de Lipoxigenase
/
Ratos Wistar
/
P-Metoxi-N-metilfenetilamina
/
Edema
Idioma:
Inglês
Revista:
Indian J Exp Biol
Ano de publicação:
1999
Tipo de documento:
Artigo
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