Wound healing activity of Sesamum indicum L seed and oil in rats.
Indian J Exp Biol
;
2008 Nov; 46(11): 777-82
Artigo
em Inglês
| IMSEAR
| ID: sea-56210
ABSTRACT
The seeds of S. indicum L (Pedaliaceae) are used traditionally in the folklore for the treatment of various kinds of wounds. The present study was undertaken to verify the effect of S. indicum seeds and its oil on experimentally induced excision wound, incision wound, burn wound and dead space wound models in rats. Aloe vera was used as standard wound healing agent. A formulation of seeds and oil was prepared in carbopol at 2.5% and 5% concentrations and applied to the wounds. In the excision and burn wound models, the so treated animals showed significant reduction in period of epithelization and wound contraction (50%). In the incision wound model a significant increase in the breaking strength was observed. Seeds and oil treatment (250 mg and 500 mg/kg; po) in dead space wound model, produced a significant increase in the breaking strength, dry weight and hydroxyproline content of the granulation tissue. The results suggest that S. indicum seeds and oil applied topically or administered orally possesses wound healing activity.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Ratos
/
Sementes
/
Cicatrização
/
Ferimentos Penetrantes
/
Óleos de Plantas
/
Queimaduras
/
Masculino
/
Extratos Vegetais
/
Administração Oral
/
Ratos Wistar
Idioma:
Inglês
Revista:
Indian J Exp Biol
Ano de publicação:
2008
Tipo de documento:
Artigo
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