Lethal, oedema, haemorrhagic activity of spotted butterfish (Scatophagus argus, Linn) sting extract and its neutralization by antiserum and pharmacological antagonists.
Indian J Exp Biol
;
2005 Jun; 43(6): 493-7
Artigo
em Inglês
| IMSEAR
| ID: sea-56276
ABSTRACT
An attempt has been made in this communication to develop antiserum in rabbit against Scatophagus. argus sting extract. Antiserum did not neutralized the sting extract induced proinflammatory and haemorrhagic activity but successfully neutralized lethality upto 2LD50. Cyproheptadine, indomethacin and BW 755C pretreatment significantly reduced sting extract induced proinflammatory activity. The haemorrhagic activity of sting extract was significantly inhibited by temperature, UV-exposure, EDTA, cyproheptadine, indomethacin and BW 755C pretreatment. The results conclude that the local effects of S.argus venom is likely to be mediated through release of mediators and may be encountered by pharmacological antagonists better than the antiserum.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Coelhos
/
Ratos
/
Temperatura
/
Fatores de Tempo
/
Raios Ultravioleta
/
Perciformes
/
Masculino
/
Indometacina
/
4,5-Di-Hidro-1-(3-(Trifluormetil)Fenil)-1H-Pirazol-3-Amina
/
Ácido Edético
Idioma:
Inglês
Revista:
Indian J Exp Biol
Ano de publicação:
2005
Tipo de documento:
Artigo
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