Effect of cyproheptadine on glucose tolerance, serum insulin and structure of pancreatic islets in rats.

Chakrabarty, A S; Pourany, A; Ananthanarayanan, P H; Subramanian, N; Rathinaswamy, P; Chakrabarty, K

Chakrabarty, A S; Pourany, A; Ananthanarayanan, P H; Subramanian, N; Rathinaswamy, P; Chakrabarty, K.

Indian J Exp Biol ; 1990 Aug; 28(8): 721-3

Artigo em Inglês | IMSEAR | ID: sea-56281

ABSTRACT

ABSTRACT

The effect of cyproheptadine (CPH) on glucose tolerance, serum immunoreactive insulin (IRI) and structure of pancreatic islets in albino rats has been studied. Hyperglycemia with glucose intolerance was observed after 10 days of administration of CPH (40 mg/kg, ip). There was insignificant change of fasting IRI after the treatment. Histological studies indicated degranulation and vacuolation of beta cells with enlargement of capillaries. Improvement in blood glucose, glucose tolerance and structure of islets with proliferation of small pancreatic ducts and cell cords were observed 10 days after the withdrawal of CPH.

Assuntos

Animais; Glicemia/análise; Ciproeptadina/farmacologia; Grânulos Citoplasmáticos/efeitos dos fármacos; Teste de Tolerância a Glucose; Hiperglicemia/induzido quimicamente; Insulina/sangue; Ilhotas Pancreáticas/efeitos dos fármacos; Masculino; Ratos; Ratos Endogâmicos

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Texto completo: DisponíveL Índice: IMSEAR (Sudeste Asiático) Assunto principal: Ratos / Ratos Endogâmicos / Glicemia / Masculino / Ilhotas Pancreáticas / Ciproeptadina / Grânulos Citoplasmáticos / Teste de Tolerância a Glucose / Hiperglicemia / Insulina Idioma: Inglês Revista: Indian J Exp Biol Ano de publicação: 1990 Tipo de documento: Artigo

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