Comparative interaction of few antihypertensive drugs with cyclosporine-A in rats.
Indian J Exp Biol
;
2007 Jul; 45(7): 638-41
Artigo
em Inglês
| IMSEAR
| ID: sea-56333
ABSTRACT
The maximal endothelial dependent relaxation of isolated aortic rings to cumulative doses of acetylcholine was significantly decreased in the Cyclosporine-A (CSA, 20 mg kg(-1) day(-1)) treated animals compared to olive oil (CSA vehicle) treated control. Administration of antihypertensive drugs like diltiazem, enalapril or propranolol to CSA treated animals augmented the endothelial damage induced by CSA. These drugs also increased the bioavailability of CSA. However, administration of losartan to CSA treated animals produced a significant increase in endothelial dependent relaxation as compared to CSA treated control but did not affect the bioavailability of CSA significantly. The results suggest that losartan is safer compared to other antihypertensives for the treatment of CSA induced hypertension.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Aorta Torácica
/
Propranolol
/
Ratos
/
Óleos de Plantas
/
Masculino
/
Diltiazem
/
Enalapril
/
Acetilcolina
/
Cromatografia Líquida de Alta Pressão
/
Ciclosporina
Idioma:
Inglês
Revista:
Indian J Exp Biol
Ano de publicação:
2007
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS