Interrelation of xanthine oxidase and dehydrogenase and L-gulonolactone oxidase in animal tissues.
Indian J Exp Biol
;
1991 Jun; 29(6): 574-8
Artigo
em Inglês
| IMSEAR
| ID: sea-56471
ABSTRACT
There is a correlation between phylogeny and the activities of L-gulonolactone oxidase (LGO), the key enzyme responsible for ascorbic acid (AH2) synthesis in animals and total xanthine oxidase and dehydrogenase [XOD(D/O)], the enzyme responsible for the production of endogenous superoxide radical (O2-.). LGO appears in the kidneys of amphibians and reptiles but livers of mammals. XOD(D/O) also is present mainly in the kidneys of amphibians and reptiles and livers of mammals. AH2 is a potential scavenger of O2-. and it appears that tissue specific expression of LGO takes place to counteract the endogenous O2-. toxicity. The interrelation of XOD(D/O) and LGO was also observed in the liver of rats during prenatal to postnatal development.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Anuros
/
Oxigênio
/
Répteis
/
Desidrogenase do Álcool de Açúcar
/
Xantina Desidrogenase
/
Xantina Oxidase
/
L-Gulonolactona Oxidase
/
Fígado
/
Animais
/
Mamíferos
Idioma:
Inglês
Revista:
Indian J Exp Biol
Ano de publicação:
1991
Tipo de documento:
Artigo
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