Perturbations in phosphoinositide metabolism and protein kinase C activity in mouse liver following whole body irradiation.
Indian J Exp Biol
;
1999 Nov; 37(11): 1075-9
Artigo
em Inglês
| IMSEAR
| ID: sea-56604
ABSTRACT
The involvement of the signal transduction pathway in mouse liver following whole body irradition was investigated. Mice were exposed to 60Co gamma rays (3 Gy) and sacrificed after different time intervals. Various elements of phosphatidyl inositol signal transduction pathway were investigated. Alterations could be seen as early as 15 min of irradiation. These changes are reflected in elevation in DAG levels and increased activation of PKC, an enzyme which is involved in tumorigenesis. The chronological appearance of various transducers following whole body irradiation is of significance since these early effects may set the stage for radiation-induced tumorigenesis and hence may be used to manipulate tumor response to radiotherapy.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Fosfatidilinositóis
/
Proteína Quinase C
/
Masculino
/
Transdução de Sinais
/
Irradiação Corporal Total
/
Diglicerídeos
/
Raios gama
/
Fígado
/
Animais
/
Camundongos
Idioma:
Inglês
Revista:
Indian J Exp Biol
Ano de publicação:
1999
Tipo de documento:
Artigo
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