Effect of RMI 12,936, an antiprogestational steroid on decidual cell reaction and embryos in rat.
Indian J Exp Biol
;
1992 Apr; 30(4): 342-3
Artigo
em Inglês
| IMSEAR
| ID: sea-56610
ABSTRACT
Subcutaneous administration of RMI 12,936 at a dose level of 2 mg/rat on day 5 of unilaterally pregnant rat having trauma-induced decidual cell reaction (DCR) in the contralateral uterine horn, suppresses DCR, induces resorption of implanted embryos and leads to decrease in the plasma level of progesterone. Progesterone replacement (D 5-8) in this situation reverses DCR suppressive effect of RMI 12,936 but fails to prevent resorption of implanted embryos. It is concluded that possibly the drug simultaneously exerts embryotoxic as well as luteolytic effects, but these effects are independent.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Progesterona
/
Ratos
/
Ratos Endogâmicos
/
Feminino
/
Gravidez
/
Anticoncepcionais Sintéticos Pós-Coito
/
Decídua
/
Feto
/
Injeções Subcutâneas
/
Androstenóis
Idioma:
Inglês
Revista:
Indian J Exp Biol
Ano de publicação:
1992
Tipo de documento:
Artigo
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