Effect of cisplatin on physiological status of normal rat testis.

ABSTRACT

Effects of cisplatin with or without testosterone on the physiology of normal adult rats were studied. The weights of epididymis, seminal vesicles and ventral prostate showed the decreased level of testosterone in cisplatin-treated rats. There was no change in DNA, RNA and protein contents in both cisplatin and cisplatin-testosterone treated animals. Hence it is suggested that the administration of cisplatin does not inhibit DNA, RNA and protein synthesis in the testis of normal rats. It could be due to either the normal cells are able to oppose the cross links formation or their removal at faster rate than in tumor cells by repair mechanisms or proteins which the tumor cells lack.