Role of iron and copper during benzene toxicity.
Indian J Exp Biol
;
1998 Mar; 36(3): 283-6
Artigo
em Inglês
| IMSEAR
| ID: sea-56667
ABSTRACT
Role of transition metal ions in expression of benzene toxicity has been suggested. Intraperitoneal administration of benzene to female albino rats daily for 10 days resulted in accumulation of iron in liver nuclei, without any change in copper content. Incubation of hydroquinone (HQ), one of the principal metabolites of benzene with rat liver nuclei resulted in formation of thiobarbituric acid reactive products (TBAR). However, presence of bathocuproine, a copper chelator and EDTA, an iron chelator caused significant inhibition of TBAR release. Thus, the present study revealed that iron accumulation and involvement of copper in nuclear damage induced by HQ.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Ratos
/
Benzeno
/
Feminino
/
Masculino
/
Núcleo Celular
/
Sequestradores de Radicais Livres
/
Substâncias Reativas com Ácido Tiobarbitúrico
/
Cobre
/
Ferro
/
Fígado
Idioma:
Inglês
Revista:
Indian J Exp Biol
Ano de publicação:
1998
Tipo de documento:
Artigo
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