Reversal of T-cell unresponsiveness through serine-esterase inhibitors mediated enhanced lymphokine induced microbicidal activities in kala-azar.
Indian J Exp Biol
;
1992 Jan; 30(1): 54-6
Artigo
em Inglês
| IMSEAR
| ID: sea-56724
ABSTRACT
After presenting processed glycoprotein of Leishmania donovani to T-cell, macrophage seeks the help of a panel of T-cells lymphokines to transform from a state that sustains intra cellular replication of parasite to an effector state for destructing parasites. But esterase and trypsin of macrophage membrane prevent T-cells to release MIF. Role of soya-bean trypsin inhibitor (STI) has been exposed in the present study with a view to alter esterase functional behaviour of macrophage for control of T-cell activation and also, if T-cells once made responsive to antigen by STI do alter macrophage response to T-cells or not. Results establish STI as potent effector molecule, which can serve as an adjuvant to candidate T-cell epitope and synthetic peptide for development of anti-Kala-azar vaccine protocol in future.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Inibição de Migração Celular
/
Ativação Linfocitária
/
Linfócitos T
/
Inibidores da Tripsina
/
Citotoxicidade Imunológica
/
Relação Dose-Resposta a Droga
/
Imunidade Celular
/
Leishmaniose Visceral
/
Ativação de Macrófagos
/
Macrófagos
Idioma:
Inglês
Revista:
Indian J Exp Biol
Ano de publicação:
1992
Tipo de documento:
Artigo
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