Beneficial effect of modified egg on serum T3, T4 and dyslipidaemia following dietary Zn-supplementation in Wistar rat.

ABSTRACT

A fall in serum T3 and T4 along with increase in serum cholesterol, triglycerides, LDL-c and VLDL-c and decrease in HDL-c was observed in albino Wistar rats when fed on semi-synthetic diet containing either 40 or 80mg Zn/kg diet. Zn concentrations were observed to increase with decreased concentration of Cu and Mg in their tissues. On including modified egg (Indian Patent Application No. 2264\Del\2005) in the Zn supplement diet, the levels of T3 and T4, lipid profile in serum and mineral status approached closer to control group-I. The data suggest that hypothyroidism and dyslipidaemia caused by excessive Zn in diet can be ameliorated on consuming these modified eggs due to restoration of mineral status in the body.