Release of iron from haemoglobin--a possible source of free radicals in diabetes mellitus.
Indian J Exp Biol
;
1999 Feb; 37(2): 190-2
Artigo
em Inglês
| IMSEAR
| ID: sea-56902
ABSTRACT
Increased blood glucose in diabetes mellitus stimulates nonenzymatic glycosylation of several proteins, including haemoglobin. Although iron is tightly bound to haemoglobin, it is liberated under specific circumstances yielding free reactive iron. Studies with purified haemoglobin from normal individuals and diabetic patients revealed that concentration of free iron was significantly higher in the latter cases and increased progressively with extent of the disease. In vitro glycosylation of haemoglobin also led to increase in release of iron from protein. This increase in free iron, acting as a Fenton reagent, might produce free radicals, which, in turn might be causing oxidative stress in diabetes.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Humanos
/
Hemoglobinas Glicadas
/
Hemoglobinas
/
Estudos de Casos e Controles
/
Estresse Oxidativo
/
Diabetes Mellitus
/
Radicais Livres
/
Ferro
Tipo de estudo:
Estudo observacional
Idioma:
Inglês
Revista:
Indian J Exp Biol
Ano de publicação:
1999
Tipo de documento:
Artigo
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