Ascorbic acid delays the development of tolerance to amphetamine induced anorexia but does not affect the reverse tolerance which develops to the locomotor activity.
Indian J Exp Biol
;
1994 Aug; 32(8): 540-3
Artigo
em Inglês
| IMSEAR
| ID: sea-57050
ABSTRACT
Ascorbic acid (1 g/kg) accentuated anorectic and locomotor effects of amphetamine (5 mg/kg) and delayed development of tolerance to anorectic effect. On the contrary, it did not alter the pattern of reverse tolerance to increased locomotor activity. The results suggest that modulation of dopamine receptor sensitivity by ascorbic acid may be the reason for the delay in development of tolerance to amphetamine induced anorexia.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Ácido Ascórbico
/
Ratos
/
Masculino
/
Anorexia
/
Ratos Wistar
/
Tolerância a Medicamentos
/
Anfetamina
/
Animais
/
Atividade Motora
Idioma:
Inglês
Revista:
Indian J Exp Biol
Ano de publicação:
1994
Tipo de documento:
Artigo
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