Anti-inflammatory and analgesic activity of Indian Hypericum perforatum L.
Indian J Exp Biol
;
2001 Apr; 39(4): 339-43
Artigo
em Inglês
| IMSEAR
| ID: sea-57237
ABSTRACT
A standardised 50% aqueous ethanolic extract of the Indian variety of Hypericum perforatum (IHp) was examined for its putative anti-inflammatory and analgesic activity at the doses of 100 and 200 mg/kg, po. The experimental paradigms used were carrageenan induced pedal edema and cotton pellet induced granuloma for anti-inflammatory activity, whereas the tail flick, hot plate and acetic acid induced writhing methods were used to asses analgesic activity. Indomethacin (20 mg/kg, ip) was used as the standard anti-inflammatory drug. Pentazocine (10 mg/kg, ip) and aspirin (25 mg/kg, ip), both clinically used analgesics, were used as standard analgesics for comparison. IHp extract showed significant anti-inflammatory and analgesic activity at both dose levels, in all the paradigms used. Additionally, IHp potentiated the anti-inflammatory activity of indomethacin and analgesic activities of pentazocine and aspirin.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Pentazocina
/
Plantas Medicinais
/
Ratos
/
Feminino
/
Masculino
/
Extratos Vegetais
/
Granuloma de Corpo Estranho
/
Anti-Inflamatórios não Esteroides
/
Aspirina
/
Limiar da Dor
Idioma:
Inglês
Revista:
Indian J Exp Biol
Ano de publicação:
2001
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS